Moon craters in the brain: the striking lesions of Baló’s concentric sclerosis in a young adult

Abstract Background Baló’s concentric sclerosis (BCS) is a rare demyelinating disorder distinguished by its hallmark imaging feature of concentric layers of demyelination on magnetic resonance imaging (MRI). Despite its distinct radiological presentation, the pathogenesis and clinical significance of BCS remain poorly understood, making the reporting of such cases crucial for advancing knowledge about its diagnosis and management. Through this case report, we aimed to highlight the clinical and radiological features of BCS and emphasise the role of MRI in its early diagnosis and management. Case presentation We present a case of BCS characterised by a severe clinical presentation and a striking radiological profile. The patient exhibited profound neurological deficits, and a brain MRI was performed, demonstrating the hallmark concentric demyelination pattern. Diagnosis was based on clinical presentation and characteristic imaging findings. High-dose corticosteroid therapy led to significant clinical recovery and marked radiological improvement. Conclusions This case contributes to a deeper understanding of the pathophysiological processes behind BCS and underscores the importance of recognising its characteristic imaging features. Improved awareness may enhance diagnostic accuracy and influence therapeutic approaches for this rare condition.

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Publication Details

Journal
The Egyptian Journal of Radiology and Nuclear Medicine
Published
2025-08-18
DOI
https://doi.org/10.1186/s43055-025-01546-6
Primary Topic
Genetic Neurodegenerative Diseases
Type
article
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article

Moon craters in the brain: the striking lesions of Baló’s concentric sclerosis in a young adult

Ismail Mohamed Halfi, Meriem Fikri, Firdaous Touarsa, Mohamed Jiddane
The Egyptian Journal of Radiology and Nuclear Medicine
Genetic Neurodegenerative Diseases
article

Moon craters in the brain: the striking lesions of Baló’s concentric sclerosis in a young adult

Ismail Mohamed Halfi, Meriem Fikri, Firdaous Touarsa, Mohamed Jiddane
article en

Abstract

Abstract Background Baló’s concentric sclerosis (BCS) is a rare demyelinating disorder distinguished by its hallmark imaging feature of concentric layers of demyelination on magnetic resonance imaging (MRI). Despite its distinct radiological presentation, the pathogenesis and clinical significance of BCS remain poorly understood, making the reporting of such cases crucial for advancing knowledge about its diagnosis and management. Through this case report, we aimed to highlight the clinical and radiological features of BCS and emphasise the role of MRI in its early diagnosis and management. Case presentation We present a case of BCS characterised by a severe clinical presentation and a striking radiological profile. The patient exhibited profound neurological deficits, and a brain MRI was performed, demonstrating the hallmark concentric demyelination pattern. Diagnosis was based on clinical presentation and characteristic imaging findings. High-dose corticosteroid therapy led to significant clinical recovery and marked radiological improvement. Conclusions This case contributes to a deeper understanding of the pathophysiological processes behind BCS and underscores the importance of recognising its characteristic imaging features. Improved awareness may enhance diagnostic accuracy and influence therapeutic approaches for this rare condition.

The Egyptian Journal of Radiology and Nuclear MedicineVol. 56(1)
Mohammed V University (MA)
Openalex Percentile: Top 77%
Genetic Neurodegenerative Diseases
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