Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Colon Microbiome In Vitro
This novel finding suggests that while bacteria capable of converting choline to TMA exist throughout the colon, their activity may be different in distinct colon regions. The regional specificity of TMA production, if confirmed in vivo, has implications for both basic microbial ecology related to CVD and the development of strategies to control TMA and TMAO production, with the goal of lowering CVD risk. These findings warrant further study in vitro and in vivo.
Authors
- Andrew P. Neilson (ORCID: https://orcid.org/0000-0001-5497-663X)
- Anthony M. Buckley (ORCID: https://orcid.org/0000-0002-2790-0717)
- Michael G. Sweet (ORCID: https://orcid.org/0000-0001-6547-1602)
- Sarah Zaidan (ORCID: https://orcid.org/0000-0002-5018-8297)
- William Davis Birch (ORCID: https://orcid.org/0000-0002-3352-1721)
- Duncan Ewin (ORCID: https://orcid.org/0000-0001-6044-5368)
- Ashley M McAmis
- Juanita G. Ratliff
- Aliyah Alkazemi
Institutions
- University of Leeds (GB)
- North Carolina State University (US)
Publication Details
- Journal
- Metabolites
- Published
- 2025-08-16
- DOI
- https://doi.org/10.3390/metabo15080552
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Biotechnology and Biological Sciences Research Council