GSTP1-mediated inhibition of ACSL4-dependent ferroptosis via JNK pathway in DOX-induced cardiomyopathy
This study identifies the DOX/GSTP1/JNK axis as a critical pathway mediating ACSL4-dependent ferroptosis in DIC. GSTP1 is highlighted as a potential key mediator of ferroptosis and a promising therapeutic target for DIC.
Authors
- Xin Ping Yang (ORCID: https://orcid.org/0000-0003-0222-5839)
- Wenwu Ling (ORCID: https://orcid.org/0000-0002-6449-3831)
- Z Li
- Xueli Hu
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Dong Li (ORCID: https://orcid.org/0000-0002-8680-0468)
- Siyi Chen (ORCID: https://orcid.org/0000-0002-0153-6152)
- Xiaomiao Ruan (ORCID: https://orcid.org/0000-0002-8658-0100)
- Ye Zhao
- Mingbo Wu (ORCID: https://orcid.org/0000-0003-2157-7469)
- Jiaojiao Zhou (ORCID: https://orcid.org/0000-0001-8128-4735)
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Military General Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1097/cm9.0000000000003758
- Citations
- 1
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81