Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation

Sirt1 is significantly reduced in CaOx-induced nephropathy models in vivo and calcium oxalate monohydrate (COM) induced in vitro. Sirt1 in macrophages alleviated CaOx-induced kidney injury and crystal deposition via elevating itaconate levels. Conditional knockout of Sirt1 in vivo significantly exacerbates renal crystal deposition and function damage. We accurately evaluated CaOx-induced renal inflammation status by micro <sup>18</sup>F-FDG PET/CT, and observed macrophage phagocytosis and encapsulation of crystals exposed to epithelial cells through scanning electron microscopy. Sirt1 agonists can be used as preventative and therapeutic agents for CaOx nephropathy, and exogenous supplementation of itaconate effectively alleviated renal crystallisation and inflammatory damage.

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Publication Details

Journal
Clinical and Translational Medicine
Published
2025-08-01
DOI
https://doi.org/10.1002/ctm2.70450
Citations
1
Primary Topic
Heme Oxygenase-1 and Carbon Monoxide
Type
article
Field-Weighted Citation Impact
0.81

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article

Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation

Xiaoliang Wu, Xinghuan Wang, Yan Gong, Sheng Li et al.
1 citations
Clinical and Translational Medicine
Heme Oxygenase-1 and Carbon Monoxide
0.81
article

Sirtuin1 mitigation of calcium oxalate nephropathy via enhancing itaconate abundance through reduction of histone trimethylation

Xiaoliang Wu, Xinghuan Wang, Yan Gong, Sheng Li, Bo Li, Haoran Liu, Yangjun Zhang, Chen Duan, Tongzu Liu, Xiangyang Yao, Hua Xu
article en
1 citations

Abstract

Sirt1 is significantly reduced in CaOx-induced nephropathy models in vivo and calcium oxalate monohydrate (COM) induced in vitro. Sirt1 in macrophages alleviated CaOx-induced kidney injury and crystal deposition via elevating itaconate levels. Conditional knockout of Sirt1 in vivo significantly exacerbates renal crystal deposition and function damage. We accurately evaluated CaOx-induced renal inflammation status by micro <sup>18</sup>F-FDG PET/CT, and observed macrophage phagocytosis and encapsulation of crystals exposed to epithelial cells through scanning electron microscopy. Sirt1 agonists can be used as preventative and therapeutic agents for CaOx nephropathy, and exogenous supplementation of itaconate effectively alleviated renal crystallisation and inflammatory damage.

Clinical and Translational MedicineVol. 15(8)
University of Science and Technology of China (CN), Anhui Medical University (CN), Wuhan University (CN), Zhongnan Hospital of Wuhan University (CN), First Affiliated Hospital of Anhui Medical University (CN), First Affiliated Hospital of Zhengzhou University (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Anhui Postdoctoral Science Foundation
Good health and well-being
Openalex Percentile: Top 25%
Heme Oxygenase-1 and Carbon Monoxide
0.81
DOIOpen Access PDFOpenAlex
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