Unraveling the causal role of TGF-βRII in osteoporosis and the potential of its associated differential genes as novel targets
TGFBRII was found to be causally associated with OP. ID2, ID4, LRRC32, and EMP3 affect the differentiation and osteogenic function of bone marrow MSCs through the TGF-β pathway, suggesting the potential of ID2, ID4, LRRC32, and EMP3 as therapeutic targets for treating osteoporosis. In summary, targeting of ID2, ID4, LRRC32, and EMP3 holds significant promise for the treatment of OP, providing new targets and strategies, and precise treatment.
Authors
- Yueyang Fan (ORCID: https://orcid.org/0009-0009-6040-0819)
- Chen Zhang (ORCID: https://orcid.org/0000-0003-0205-0928)
- Wenyu Wang (ORCID: https://orcid.org/0009-0005-5624-0657)
- Rui Wu (ORCID: https://orcid.org/0000-0002-7938-0194)
- Ziquan Yang (ORCID: https://orcid.org/0000-0002-1862-3922)
- Xinyu Zhu (ORCID: https://orcid.org/0009-0003-5767-1120)
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s40001-025-02971-z
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61