Curcumin inhibits ferroptosis through dessuccinylation of SIRT5-associated ACSL4 protein, and plays a chondroprotective role in osteoarthritis
Cur protects chondrocytes in vitro by inhibiting ferroptosis and suppresses cartilage degeneration and bone erosion in vivo, demonstrating a chondroprotective role in OA. These effects are mediated through SIRT5-dependent desuccinylation of ACSL4, which regulates ferroptosis pathways.
Authors
- X Ye
- Yongxia Li (ORCID: https://orcid.org/0000-0001-6824-9943)
- Lei Liu (ORCID: https://orcid.org/0000-0003-3452-4323)
- Yong X. Xu (ORCID: https://orcid.org/0000-0002-9746-6004)
- Qingling Jing
Institutions
- Qinghai University Affiliated Hospital (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1371/journal.pone.0328139
- Citations
- 4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22