Red Cell Transfusion in Acute Myocardial Infarction: AABB International Clinical Practice Guidelines

For hospitalized patients with AMI, the panel suggests a liberal red cell transfusion strategy when the hemoglobin concentration is less than 10 g/dL (conditional recommendation, low-certainty evidence). A restrictive strategy of 7 to 8 g/dL may result in increased mortality in patients with AMI. The direction of the recommendation for the liberal strategy was based on the great importance of mortality for patients. The conditional recommendation was based on the low certainty of evidence and the competing consideration of blood supply conservation. Clinicians should adopt mitigation strategies to reduce potential adverse events associated with a liberal transfusion strategy, and all transfusion decisions should incorporate the clinical context rather than solely the hemoglobin concentration.

Authors

Institutions

Publication Details

Journal
Annals of Internal Medicine
Published
2025-08-18
DOI
https://doi.org/10.7326/annals-25-00706
Citations
7
Primary Topic
Blood transfusion and management
Type
article
Field-Weighted Citation Impact
5.42
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Red Cell Transfusion in Acute Myocardial Infarction: AABB International Clinical Practice Guidelines

Philippe Gabríel Steg, Jay S. Raval, Eric Salazar, Jeffrey L. Carson et al.
7 citations
Annals of Internal Medicine
Blood transfusion and management
5.42
article

Red Cell Transfusion in Acute Myocardial Infarction: AABB International Clinical Practice Guidelines

Philippe Gabríel Steg, Jay S. Raval, Eric Salazar, Jeffrey L. Carson, Simon Stanworth, Cynthia So‐Osman, Timothy Simon Walsh, Brenda J. Grossman, Nicholas L. Mills, Yulia Lin, Lachlan Fraser Miles, Lewis J. Kaplan, Kevin Shah, Claudia S. Cohn, Erica M. Wood, Aaron S. Hess, Nicole D. Zantek, Nabiha H. Saifee, Aaron A.R. Tobian, Micah T. Prochaska, Jonathan H. Waters, Gaurav K. Gupta, Colin Murphy, Sara Bakhtary, Ryan A. Metcalf, Monica B. Pagano, Keyvan Karkouti, Jane A Dennis, Katerina Pavenski, Allan Dubon, Gordon H. Guyatt
article en
7 citations

Abstract

For hospitalized patients with AMI, the panel suggests a liberal red cell transfusion strategy when the hemoglobin concentration is less than 10 g/dL (conditional recommendation, low-certainty evidence). A restrictive strategy of 7 to 8 g/dL may result in increased mortality in patients with AMI. The direction of the recommendation for the liberal strategy was based on the great importance of mortality for patients. The conditional recommendation was based on the low certainty of evidence and the competing consideration of blood supply conservation. Clinicians should adopt mitigation strategies to reduce potential adverse events associated with a liberal transfusion strategy, and all transfusion decisions should incorporate the clinical context rather than solely the hemoglobin concentration.

Annals of Internal MedicineVol. 178(10)
University of Vermont (US), New York City Health and Hospitals Corporation (US), St. Michael's Hospital (CA), University of Minnesota (US), NHS Blood and Transplant (GB), Sunnybrook Health Science Centre (CA), Memorial Sloan Kettering Cancer Center (US), University of Wisconsin–Madison (US), Johns Hopkins University (US), Inserm (FR), The University of Texas at San Antonio Health Science Center (US), University of Pittsburgh (US), University of California, San Francisco (US), University of Washington (US), Washington University in St. Louis (US), Queen's University (CA), Université Paris Cité (FR), University of Utah (US), Johns Hopkins Medicine (US), Southmead Hospital (GB), Women's College Hospital (CA), University of Vermont Medical Center (US), Johnson University (US), Sanquin (NL), University of Illinois Chicago (US), University of Chicago (US), Urology San Antonio (US), Assistance Publique – Hôpitaux de Paris (FR), Bellevue Hospital Center (US), Seattle Children's Hospital (US), Deseret Laboratories (United States) (US), Monash Health (AU), Radiology Associates of Albuquerque (US), Kingston Health Sciences Centre (CA), Austin Health (AU), University of Pennsylvania (US), McMaster University (CA), University of Edinburgh (GB)
Openalex Percentile: Top 4%
Blood transfusion and management
5.42
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.