Sex differences in cholesterol levels among prepubertal children
Prepubertal girls have modestly higher TC and LDL-C than boys, a difference not observed in prepubertal FH-positive children, suggesting that the presence of a pathogenic FH variant may override innate physiological differences in lipid metabolism. These findings support universal early cholesterol screening and suggest that sex-specific reference values may improve early cardiovascular risk assessment in prepubertal FH-negative children.
Authors
- Barbara Čugalj Kern
- Matej Mlinarič
- Mike Oliver Becker (ORCID: https://orcid.org/0000-0001-9102-3088)
- Urh Grošelj (ORCID: https://orcid.org/0000-0002-5246-9869)
- Jaka Šikonja (ORCID: https://orcid.org/0000-0001-7843-8107)
- Tadej Battelino (ORCID: https://orcid.org/0000-0002-0273-4732)
- Katarina Sedej
- Ana Drole Torkar (ORCID: https://orcid.org/0000-0002-0506-2919)
- Jernej Kovač (ORCID: https://orcid.org/0000-0003-3080-4838)
- Jan Kafol
- Matej Kafol
Institutions
- Ljubljana University Medical Centre (SI)
- University of Maribor (SI)
- University Clinical Centre Maribor (SI)
- Community Health Centre Ljubljana (SI)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120484
- Citations
- 5
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 17.47
Funders
- Javna Agencija za Raziskovalno Dejavnost RS