Mechanisms of developing recurrent miscarriage: the role of posttraumatic stress disorder

The rapid deterioration of the demographic situation in Ukraine highlights the particular significance of recurrent pregnancy loss (RPL). An insufficient assessment of the impact of post-traumatic stress disorder (PTSD) represents a significant gap in the current practices of diagnosis, treatment, and prevention of RPL. Aim - to identify the relationship between PTSD and RPL, and to establish a probable correlation between the severity of PTSD and dysfunction in various systems of the female body. Materials and methods. The study involved 150 women diagnosed with RPL. Depending on the presence of PTSD, participants were divided into four groups. Standardized psychodiagnostic tools (Posttraumatic Stress Disorder Checklist for Civilians (PCL-C), Clinician-Administered PTSD Scale (CAPS-5) a structured interview, Beck Depression Inventory) were used alongside clinical-laboratory, immunological, and hormonal assessment methods. Results. A statistically significant association was found between PTSD and elevated levels of NK cells, indicating activation of innate immunity. Women with PTSD more frequently presented with thyroid dysfunction, antiphospholipid syndrome, and lifestyle-related risk behaviors, such as excessive caffeine intake, alcohol consumption, and smoking. Conclusions. PTSD is an important risk factor for RPL and should be considered within interdisciplinary support programs for women with reproductive failures. The findings underscore the relevance of a comprehensive approach, including mandatory psycho-emotional assessment and intervention. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of the participating institution. Informed consent was obtained from all participants. The author declares no conflict of interest.