Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells

ELOVL6 regulates lipid composition to preserve mitochondrial function, supporting cell growth and tumorigenesis in FGFR3-mutated BC. Targeting ELOVL6 may represent a novel therapeutic strategy for treating BC, particularly in tumors driven by FGFR3 mutations.

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Institutions

Publication Details

Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Published
2025-08-18
DOI
https://doi.org/10.1016/j.bbadis.2025.168023
Citations
2
Primary Topic
Fibroblast Growth Factor Research
Type
article
Field-Weighted Citation Impact
1.61

Funders

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article

Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells

Shuya Kandori, Asuka Suzuki, Shotaro Sakka, Motohiro Sekiya et al.
2 citations
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Fibroblast Growth Factor Research
1.61
article

Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells

Shuya Kandori, Asuka Suzuki, Shotaro Sakka, Motohiro Sekiya, Yoshinori Osaki, Minako Yamamura, Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, Takahiro Kojima, Chiaki Takahashi, Hayato Muranaka, Kaori Motomura, Susumu Kohno, Takafumi Miyamoto, Hiroyuki Nishiyama, Yoshimi Nakagawa, Hiroshi Ohno, Akio Hayashi, Shiho Hasebe, Naoya Yahagi, Satoshi Nitta, Erika Matsuda, Yoshinori Takeuchi
article en
2 citations

Abstract

ELOVL6 regulates lipid composition to preserve mitochondrial function, supporting cell growth and tumorigenesis in FGFR3-mutated BC. Targeting ELOVL6 may represent a novel therapeutic strategy for treating BC, particularly in tumors driven by FGFR3 mutations.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseVol. 1871(8)
Kanazawa University (JP), University of Tsukuba (JP), Jichi Medical University (JP), Niigata University (JP)
Cancer Research Institute, Japan Agency for Medical Research and Development, Kanazawa University, Ministry of Education, Culture, Sports, Science and Technology
Good health and well-being
Openalex Percentile: Top 15%
Fibroblast Growth Factor Research
1.61
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