Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells
ELOVL6 regulates lipid composition to preserve mitochondrial function, supporting cell growth and tumorigenesis in FGFR3-mutated BC. Targeting ELOVL6 may represent a novel therapeutic strategy for treating BC, particularly in tumors driven by FGFR3 mutations.
Authors
- Shuya Kandori (ORCID: https://orcid.org/0000-0003-4621-8470)
- Asuka Suzuki
- Shotaro Sakka (ORCID: https://orcid.org/0000-0003-1395-9088)
- Motohiro Sekiya (ORCID: https://orcid.org/0000-0002-5170-9699)
- Yoshinori Osaki (ORCID: https://orcid.org/0000-0003-1425-7790)
- Minako Yamamura
- Hitoshi Shimano (ORCID: https://orcid.org/0000-0002-5562-5572)
- Takashi Matsuzaka (ORCID: https://orcid.org/0000-0002-5898-3463)
- Hirohito Sone (ORCID: https://orcid.org/0000-0003-1263-2817)
- Takahiro Kojima (ORCID: https://orcid.org/0000-0003-4150-9631)
- Chiaki Takahashi (ORCID: https://orcid.org/0000-0003-3390-9563)
- Hayato Muranaka (ORCID: https://orcid.org/0000-0003-4835-3836)
- Kaori Motomura (ORCID: https://orcid.org/0009-0008-0996-4750)
- Susumu Kohno (ORCID: https://orcid.org/0000-0002-1448-9527)
- Takafumi Miyamoto (ORCID: https://orcid.org/0000-0001-9363-2864)
- Hiroyuki Nishiyama (ORCID: https://orcid.org/0000-0001-7423-596X)
- Yoshimi Nakagawa (ORCID: https://orcid.org/0000-0001-8710-5232)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Akio Hayashi
- Shiho Hasebe
- Naoya Yahagi (ORCID: https://orcid.org/0000-0002-1823-1865)
- Satoshi Nitta (ORCID: https://orcid.org/0000-0002-2855-1061)
- Erika Matsuda (ORCID: https://orcid.org/0000-0002-9465-3007)
- Yoshinori Takeuchi (ORCID: https://orcid.org/0000-0003-2717-5719)
Institutions
- Kanazawa University (JP)
- University of Tsukuba (JP)
- Jichi Medical University (JP)
- Niigata University (JP)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.bbadis.2025.168023
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Cancer Research Institute
- Japan Agency for Medical Research and Development
- Kanazawa University
- Ministry of Education, Culture, Sports, Science and Technology