Establishment and evaluation of a patient-derived organoids-based xenograft model of primary aldosteronism using [18F]AlF-NOTA-pentixather PET/CT: bridging preclinical and clinical imaging
We established a novel PDOX model of PA and demonstrated the effectiveness of [<sup>18</sup>F]AlF-NOTA-pentixather PET/CT in both preclinical and clinical applications. This approach provides a robust translational platform for mechanistic studies and for advancing precision imaging and therapy in PA.
Authors
- Wei Wang (ORCID: https://orcid.org/0009-0006-3617-8435)
- Xuezhou Zhang (ORCID: https://orcid.org/0009-0006-7966-1013)
- Tiantian Mou (ORCID: https://orcid.org/0000-0002-0449-2706)
- Qi Miao (ORCID: https://orcid.org/0000-0003-2922-6663)
- Yuxuan Bo (ORCID: https://orcid.org/0009-0004-4776-5868)
- Zhipeng Sun (ORCID: https://orcid.org/0000-0001-9840-4705)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0002-2932-6042)
- Ning Zhang (ORCID: https://orcid.org/0009-0009-8108-6910)
- Jiahui Zhao (ORCID: https://orcid.org/0000-0002-1489-4215)
- Mingchuan Li (ORCID: https://orcid.org/0000-0001-5185-6392)
- Jian Feng Cui
- Hongzhi Mi
- Baoan Hong (ORCID: https://orcid.org/0000-0003-3323-5597)
Institutions
- Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12967-025-06979-1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00