The Cost-Effectiveness of Collagenase Injection Versus Limited Fasciectomy for Moderate Dupuytren’s Contracture: An Economic Evaluation of the Dupuytren’s Interventions Surgery Versus Collagenase Trial and a Decision Analytical Model

Collagenase was less costly and less effective than LF in treating Dupuytren's contracture. The cost-effectiveness of collagenase compared with LF was time dependent. Collagenase was highly cost-effective 1-year after treatment; however, the probability of collagenase being cost-effective declined over time. The Markov model suggested that LF is more cost-effective over a lifetime horizon. These findings emphasize the importance of longer follow-up when comparing surgical and nonsurgical interventions to fully capture overall costs and benefits.