Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes
Our findings provide novel insights into the cell type-specific role of microglial MSR1 in AD, DLB, and PDD, linking its increased phagocytic capacity to myelin defects as a common feature of neurodegenerative dementias.
Authors
- Haitao Tu (ORCID: https://orcid.org/0000-0001-7499-0682)
- Jolene Wei Ling Lee (ORCID: https://orcid.org/0009-0000-8644-7839)
- Lifeng Qiu
- Adeline Su Lyn Ng (ORCID: https://orcid.org/0000-0001-8822-8496)
- Eng‐King Tan (ORCID: https://orcid.org/0000-0003-2977-9743)
- Li Zeng (ORCID: https://orcid.org/0000-0003-3242-2286)
- Richard Reynolds (ORCID: https://orcid.org/0000-0003-4622-4694)
- Salvatore Albani (ORCID: https://orcid.org/0000-0002-5602-6256)
- Zigang Li (ORCID: https://orcid.org/0000-0002-6668-5589)
- Mengwei Li (ORCID: https://orcid.org/0000-0001-6163-2827)
- Jinmiao Chen (ORCID: https://orcid.org/0000-0001-7547-6423)
- Jingjing Ling (ORCID: https://orcid.org/0000-0002-8028-6891)
- Sook‐Yoong Chia
Institutions
- Agency for Science, Technology and Research (SG)
- Nanyang Technological University (SG)
- Singapore General Hospital (SG)
- Singapore Immunology Network (SG)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
- Imperial College London (GB)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s13073-025-01519-4
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- Agency for Science, Technology and Research