lncRNA EGOT across cancers: TCGA analysis

Introduction long-non-coding RNAs (lncRNAs) are important new players in the epigenetic control of cellular phenotypes. One of the lncRNAs is the eosinophil granule ontogeny transcript (EGOT), in which changes in expression levels are correlated with pathological conditions, including tumorigenesis and viral infections. In spite of many studies, the biological role and diagnostics utility of EGOT remains unclear. Material and methods EGOT was analyzed based on the TCGA, including pathological and clinical features, cellular pathways, and genomic and cellular changes. Results We observed an association of higher EGOT expression with better survival in breast invasive carcinoma (BRCA), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC) and worse patients' survival for liver hepatocellular carcinoma (LIHC). Expression levels of EGOT differ in the case of HNSC, KIRC and LIHC. Critical cellular pathways and processes are changed depending on the EGOT. Moreover, immune profile, cancer subtypes, and differences in the proliferation, wound healing ability, stromal fraction, and intratumor heterogeneity depending on these lncRNA levels were noticed and differ mostly for BRCA and KIRC. Conclusions EGOT seems to be a potential prognostic biomarker in clinical use. One of the possibilities that connected all of the analyzed types of cancers and changes in EGOT expression is viral activity and immunological response to viral infection.