First-trimester combined screening for preeclampsia in twin pregnancies—results of the first 100 twin pregnancies included in the IPSISS (Implementing Preeclampsia Screening in Switzerland) cohort

This study demonstrated that, in our cohort, the markers performed as expected in twin compared with singleton pregnancies, and that at a fixed screen positive rate, fewer twin pregnancies with subsequent preeclampsia were detected compared with singleton pregnancies. Our preliminary results showed that a higher cutoff than 1:100, with a corresponding higher screen positive rate, must be chosen when screening for preterm preeclampsia in twin pregnancies to achieve an acceptable detection rate.

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Publication Details

Journal
American Journal of Obstetrics & Gynecology MFM
Published
2025-08-18
DOI
https://doi.org/10.1016/j.ajogmf.2025.101760
Citations
2
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
4.11
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article

First-trimester combined screening for preeclampsia in twin pregnancies—results of the first 100 twin pregnancies included in the IPSISS (Implementing Preeclampsia Screening in Switzerland) cohort

Gwendolin Manegold‐Brauer, Cécile Monod, Sofia Amylidi‐Mohr, Thabea Musik et al.
2 citations
American Journal of Obstetrics & Gynecology MFM
Pregnancy and preeclampsia studies
4.11
article

First-trimester combined screening for preeclampsia in twin pregnancies—results of the first 100 twin pregnancies included in the IPSISS (Implementing Preeclampsia Screening in Switzerland) cohort

Gwendolin Manegold‐Brauer, Cécile Monod, Sofia Amylidi‐Mohr, Thabea Musik, Daniel Surbek, Lauren R. Schaffer, A Hernádi, Sara Ardabili, Beatrice Mosimann, Begoña Martínez de Tejada, Pascal Challande, Sonia Campelo, Carolin Blume, Amr Hamza, Fabienne Trottmann, M Hänel, Luigi Raio, Lutz Hildebrandt, Joachim Kohl, C. Granado, Markus Hodel
article en
2 citations

Abstract

This study demonstrated that, in our cohort, the markers performed as expected in twin compared with singleton pregnancies, and that at a fixed screen positive rate, fewer twin pregnancies with subsequent preeclampsia were detected compared with singleton pregnancies. Our preliminary results showed that a higher cutoff than 1:100, with a corresponding higher screen positive rate, must be chosen when screening for preterm preeclampsia in twin pregnancies to achieve an acceptable detection rate.

American Journal of Obstetrics & Gynecology MFMVol. 7(10)
University of Geneva (CH), University of Bern (CH), University of Lucerne (CH), University of Basel (CH), University Hospital of Bern (CH), University Hospital of Basel (CH), University Hospital of Geneva (CH), Kantonsspital Baden (CH), Kantonsspital Graubünden (CH), Geneva College (US)
Openalex Percentile: Top 7%
Pregnancy and preeclampsia studies
4.11
DOIOpen Access PDFOpenAlex
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