Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy
We demonstrated that the cALG8/CLK1/SRSF7 axis promotes ATM expression by enhancing the splicing of ATM203, thereby facilitating gemcitabine resistance and formation of an immunosuppressive microenvironment in PDAC. This insight aids in the development of drugs targeting chemotherapy resistance induced by DNA damage repair mechanisms in PDAC.
Authors
- Cheng‐Yu Liao (ORCID: https://orcid.org/0000-0001-7221-7522)
- Zuwei Wang
- Yi-Feng Tian
- Xiaoxiao Huang (ORCID: https://orcid.org/0000-0002-4623-2005)
- Yinghao Chen (ORCID: https://orcid.org/0000-0002-9176-8394)
- Hongyi Lin
- Zhiyuan Li (ORCID: https://orcid.org/0000-0001-5963-4225)
- Shi Chen (ORCID: https://orcid.org/0000-0002-8207-7479)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Chun Zhang (ORCID: https://orcid.org/0000-0003-4422-173X)
- Shun‐Cang Zhu (ORCID: https://orcid.org/0000-0002-6975-3583)
- Haoxiang Zhang (ORCID: https://orcid.org/0000-0002-6302-0901)
- Chengke Xie (ORCID: https://orcid.org/0000-0002-7969-2761)
- Jianfei Hu
- Yongding Wu (ORCID: https://orcid.org/0009-0000-4874-2589)
- Jianlin Lai (ORCID: https://orcid.org/0009-0006-6595-6961)
- Jinpeng Lu
- Yueyi Weng
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.drup.2025.101292
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 2.42