METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance
In summary, we found that METTL16-mediated GPX4 modification promoted the proliferation and AZD-9291 resistance of NSLCL by inhibiting ferroptosis activity. Our study is expected to provide a novel insight and potential therapeutic target for NSCLC AZD-9291 resistance.
Authors
- Zhe Fan (ORCID: https://orcid.org/0000-0002-2446-1122)
- Bin Dai (ORCID: https://orcid.org/0000-0001-5978-4522)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-1090-2174)
- Meng Wang (ORCID: https://orcid.org/0000-0002-1573-0255)
- Jia Chen (ORCID: https://orcid.org/0000-0001-6608-1518)
- Yun‐Long Wu (ORCID: https://orcid.org/0000-0001-6426-6340)
- Di Qiao
- Yingou Zeng
Institutions
- University of Electronic Science and Technology of China (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12885-025-14729-1
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22