Gastrointestinal flora and serum metabolomic elucidation of Astragali Radix water decoction intervention in subclinical bovine mastitis
The findings establish that ARWD alleviates SCBM through coordinated microbiota remodeling and metabolic reprogramming, specifically enhancing antioxidant defenses, restoring mammary barrier integrity, and modulating immune-inflammation crosstalk, with optimal efficacy at 0.4 g·kg<sup>-1</sup>·d<sup>-1</sup> dosage. This mechanistic validation positions ARWD as a scientifically grounded, eco-friendly alternative for sustainable mastitis management, reconciling therapeutic effectiveness with agricultural economic priorities.
Authors
- Yanming Wei (ORCID: https://orcid.org/0000-0001-9632-1885)
- Ke Zhou
- Ji Peng (ORCID: https://orcid.org/0000-0002-4677-092X)
- Ting Ma (ORCID: https://orcid.org/0000-0002-3033-0778)
- Jianpeng Yan
Institutions
- Gansu Agricultural University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- China Animal Disease Control Center (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fvets.2025.1611467
- Primary Topic
- Milk Quality and Mastitis in Dairy Cows
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Gansu Province