Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors
Among acute ischemic stroke survivors, higher PSH is associated with worse lipid control and higher risk of recurrent vascular events. Our findings, combined with existing evidence on the role of adverse genetic profiles in blood pressure and glycemic control in this population, support the comprehensive evaluation of polygenic profiles as a cause of failed risk factor control in stroke survivors and its role in developing precision medicine tools for post-stroke clinical management.
Authors
- Cyprien Rivier (ORCID: https://orcid.org/0000-0002-1148-1829)
- Guido J. Falcone (ORCID: https://orcid.org/0000-0002-6407-0302)
- Adam de Havenon (ORCID: https://orcid.org/0000-0001-8178-8597)
- Kevin Navin Sheth (ORCID: https://orcid.org/0000-0003-2003-5473)
- Richa Sharma
- Victor M Torres Lopez (ORCID: https://orcid.org/0000-0002-2107-2922)
- Kane Wu (ORCID: https://orcid.org/0000-0002-6110-8336)
- Shufan Huo (ORCID: https://orcid.org/0000-0002-0119-7517)
- Bradford B. Worrall (ORCID: https://orcid.org/0000-0001-9386-4091)
Institutions
- Yale University (US)
- Yale New Haven Health System (US)
- University of Virginia (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1212/wnl.0000000000213966
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00