Is There a Role for Mifamurtide in Nonmetastatic High-Grade Osteosarcoma? Results From the Italian Sarcoma Group (ISG/OS-2) and Spanish Sarcoma Group (GEIS-33) Trials
In this merged analysis with a risk-adapted strategy for nonmetastatic osteosarcoma, the group with unfavorable prognoses, identified by Pgp expression, performed well when mifamurtide, combined with HDIFO in case of poor response, was administered after surgery.
Authors
- Anna Paioli (ORCID: https://orcid.org/0000-0002-8587-7893)
- Claudia Valverde (ORCID: https://orcid.org/0000-0003-4107-8616)
- Michela Pierini
- Katia Scotlandi (ORCID: https://orcid.org/0000-0001-6114-9499)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Andrea Marrari (ORCID: https://orcid.org/0000-0001-6363-9299)
- Marilena Cesari (ORCID: https://orcid.org/0000-0003-1505-758X)
- Virginia Ferraresi (ORCID: https://orcid.org/0000-0001-6419-1668)
- Massimo Serra (ORCID: https://orcid.org/0000-0003-0742-1177)
- Roberto Luksch (ORCID: https://orcid.org/0000-0002-7203-4176)
- Cristina Meazza (ORCID: https://orcid.org/0000-0002-1875-9563)
- Toni Ibrahim
- Stefano Ferrari (ORCID: https://orcid.org/0000-0003-3983-3328)
- Sebastian Dorin Asaftei (ORCID: https://orcid.org/0000-0002-3890-1686)
- Luca Coccoli (ORCID: https://orcid.org/0009-0003-5452-431X)
- Giuseppe Maria Milano (ORCID: https://orcid.org/0000-0002-0250-6043)
- María Esther Llinares Riestra
- Carla Manzitti (ORCID: https://orcid.org/0000-0002-1501-5518)
- Franca Fagioli (ORCID: https://orcid.org/0000-0002-9257-900X)
- Jaume Mora (ORCID: https://orcid.org/0000-0002-9386-5980)
- Gianni Bisogno (ORCID: https://orcid.org/0000-0003-4462-5523)
- Marco Gambarotti (ORCID: https://orcid.org/0000-0002-8080-4484)
- Emanuela Palmerini (ORCID: https://orcid.org/0000-0003-3406-6705)
- Alba Rubio‐San‐Simón (ORCID: https://orcid.org/0000-0001-6426-7423)
- Óscar Gallego (ORCID: https://orcid.org/0000-0001-5665-0967)
- Piero Picci (ORCID: https://orcid.org/0000-0002-8519-4101)
- Catalina Márquez-Vega (ORCID: https://orcid.org/0000-0002-4305-950X)
- Cristina Mata Fernández (ORCID: https://orcid.org/0000-0001-9922-0078)
- María Ángeles Vaz Salgado (ORCID: https://orcid.org/0000-0002-5913-9002)
- Elisa Carretta (ORCID: https://orcid.org/0000-0002-4534-6000)
- Angela Tamburini (ORCID: https://orcid.org/0000-0002-1496-4201)
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- University of Padua (IT)
- University of Miami (US)
- Istituto Giannina Gaslini (IT)
- Hospital de Sant Pau (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Santa Chiara (IT)
- Hospital Infantil Universitario Niño Jesús (ES)
- Meyer Children's Hospital (IT)
- Istituto Ortopedico Rizzoli (IT)
- Bambino Gesù Children's Hospital (IT)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Ospedale Regina Margherita (IT)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitario Virgen del Rocío (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Sylvester Comprehensive Cancer Center (US)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1200/jco-25-00210
- Citations
- 5
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.59