A20 (TNFAIP3) Distinguishes Attack From Remission in Pediatric Patients With Monophasic MOGAD
Reflecting the anti-inflammatory role of A20, its relative decrease during attacks might even start before the patient's first symptoms. Thus, longitudinal evaluation of A20 at (yet to identifiable) standardized time points might have prognostic implications. Serum A20 levels in pediatric patients with MOGAD may help to distinguish attacks from remission in monophasic disease courses. Consequently, A20 needs to be prospectively investigated in standardized multicentric longitudinal study designs, with a focus on diagnostic, prognostic, and therapeutic implications.
Authors
- Matthias Baumann (ORCID: https://orcid.org/0000-0003-4471-8324)
- Mareike Schimmel (ORCID: https://orcid.org/0000-0003-0076-4011)
- Steffen Leiz (ORCID: https://orcid.org/0000-0002-3279-8745)
- Markus Breu (ORCID: https://orcid.org/0000-0003-3825-5749)
- Andrea Klein (ORCID: https://orcid.org/0000-0003-2733-5911)
- Astrid Eisenkölbl (ORCID: https://orcid.org/0000-0001-5176-1262)
- Shrishti Saxena (ORCID: https://orcid.org/0000-0003-3429-5671)
- Michael Karenfort (ORCID: https://orcid.org/0000-0002-8925-3543)
- Kevin M. Rostasy (ORCID: https://orcid.org/0000-0002-2180-5321)
- Christian Lechner (ORCID: https://orcid.org/0000-0002-2720-1019)
- Tanuja Chitnis (ORCID: https://orcid.org/0000-0002-9897-4422)
- Markus Reindl (ORCID: https://orcid.org/0000-0003-2817-1402)
- Eva‐Maria Wendel (ORCID: https://orcid.org/0000-0002-5242-1830)
- Timothy B. Rooney (ORCID: https://orcid.org/0000-0003-4072-8883)
- Martin Preisel (ORCID: https://orcid.org/0000-0002-0177-9795)
- Mattia Rosso (ORCID: https://orcid.org/0000-0002-8521-4117)
- Hrishikesh Lokhande (ORCID: https://orcid.org/0000-0002-8257-1901)
Institutions
- Johannes Kepler University of Linz (AT)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Innsbruck Medical University (AT)
- Alnylam Pharmaceuticals (United States) (US)
- Medical University of South Carolina (US)
- Witten/Herdecke University (DE)
- Paracelsus Medical University (AT)
- University Hospital of Bern (CH)
- University Hospital Augsburg (DE)
- Düsseldorf University Hospital (DE)
- Olgahospital (DE)
- Kepler Universitätsklinikum (AT)
- München Klinik (DE)
- University Children’s Hospital Bern (CH)
- Klinikum Stuttgart (DE)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1212/nxi.0000000000200452
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00