Circulating Tumor DNA Genotyping of Intrinsic and Acquired Gene Alterations in Patients With Advanced Breast Cancer Receiving Palbociclib: Biomarker Results From POLARIS Study
Patients without altered <i>ESR1</i>, <i>PIK3CA</i>, <i>CCND1</i>, or <i>FGFR1</i> at baseline had better rwPFS than patients with altered genes. Genotyping analysis of ctDNA over time highlights the emergence of mutations in estrogen receptor and cell cycle pathways under selective therapeutic pressure and could guide monitoring and therapeutic sequencing for patients with HR+/HER2- ABC.
Authors
- Shibing Deng (ORCID: https://orcid.org/0000-0002-2867-263X)
- Meghan Karuturi (ORCID: https://orcid.org/0000-0001-8795-3901)
- Kamal Patel
- Hong Zhang (ORCID: https://orcid.org/0000-0002-8869-8671)
- Aditya Bardia (ORCID: https://orcid.org/0000-0003-4885-1157)
- Monica Z. Montelongo (ORCID: https://orcid.org/0009-0002-3679-7202)
- Joanne L. Blum (ORCID: https://orcid.org/0000-0002-7951-6645)
- Chetan Deshpande
- Shailendra Lakhanpal
- Yao Wang
- Yuan Liu (ORCID: https://orcid.org/0000-0002-2728-5718)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-0336-4865)
- Gabrielle Betty Rocque (ORCID: https://orcid.org/0000-0003-4188-9785)
- Eric Gauthier (ORCID: https://orcid.org/0000-0002-0160-7571)
- Steven McCune
- Debu Tripathy (ORCID: https://orcid.org/0000-0002-5711-2404)
Institutions
- WellStar Health System (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Pfizer (United States) (US)
- Texas Oncology (US)
- University of Alabama at Birmingham (US)
- St. Vincent's Birmingham (US)
- Northwest Behavioral Medicine (US)
- Central Arkansas Radiation Therapy Institute (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1200/po-24-00810
- Citations
- 1
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.52