Cabozantinib overcomes ROS1 L2086F NSCLC resistance to lorlatinib: A case report

This case highlights the clinical efficacy of cabozantinib in overcoming lorlatinib resistance mediated by the ROS1 L2086F mutation, resulting in durable clinical benefits surpassing those of conventional chemotherapy. These findings emphasize the critical role of repeated, comprehensive genomic profiling in managing refractory ROS1-positive non-small cell lung cancer and establish cabozantinib as a viable therapeutic option in this specific resistance context.