Correlation between hyperuricemia and coronary in-stent restenosis in patients with unstable angina: A retrospective study

This study investigates the correlation between hyperuricemia and the development of in-stent restenosis (ISR) following percutaneous coronary intervention (PCI) in patients with unstable angina. We analyzed clinical data from 128 patients diagnosed with unstable angina who underwent PCI. Patients were categorized into 2 groups: hyperuricemia group (34 cases) and non-hyperuricemia group (94 cases), based on the presence or absence of hyperuricemia. A multivariate Cox regression model was used to determine the correlation between hyperuricemia and the development of ISR. The proportion of patients who developed ISR following PCI was significantly higher in the hyperuricemia group (26.5%) than in the non-hyperuricemia group (13.8%) (P = .008). The results of the multivariate Cox regression model indicated that hyperuricemia was an independent predictor for the development of ISR following PCI (hazard ratio = 6.299, 95% confidence interval: 1.955-20.298, P = .002). Hyperuricemia was still substantially correlated with ISR after correction for confounders in patients with standard quantitative flow ratios following PCI (>0.89) (hazard ratio = 5.226, 95% confidence interval: 1.497-18.243, P = .010). Patients with hyperuricemia have a significantly increased risk of ISR following PCI. Patients who have undergone PCI therapy should be screened for hyperuricemia, closely monitored, and given aggressive uric acid-lowering therapy when necessary.