Dupilumab Initiation for Surgically Refractory Chronic Rhinosinusitis With Nasal Polyps Is Associated With Differential Expression of CLC and Activation of Eicosanoid Pathways
An untargeted transcriptomic analysis provided exploratory insight into key genes and pathways that can be used to help identify patients at risk for surgically refractory chronic rhinosinusitis with nasal polyps (CRSwNP). The Charcot-Leyden crystal gene, periostin and osteopontin-associated pathways, eicosanoid synthesis pathway, and prostaglandin/leukotriene metabolism pathway, among others, are associated with dupilumab prescription for surgically refractory chronic rhinosinusitis and may support early stratification of disease severity in CRSwNP patients.
Authors
- Justin H. Turner (ORCID: https://orcid.org/0000-0002-5501-9900)
- Suman R. Das (ORCID: https://orcid.org/0000-0003-2496-9724)
- Christina Dorismond (ORCID: https://orcid.org/0000-0002-4333-9763)
- Rory J. Lubner (ORCID: https://orcid.org/0000-0001-9884-2799)
- Naweed I. Chowdhury (ORCID: https://orcid.org/0000-0001-9826-4917)
- Katherine N. Cahill (ORCID: https://orcid.org/0000-0002-8549-1835)
- Mason R. Krysinski
- Ping Li (ORCID: https://orcid.org/0000-0002-6156-960X)
- Rakesh K. Chandra
- Daniel H. Lofgren (ORCID: https://orcid.org/0000-0003-3027-3694)
- Chandler J. Rygalski (ORCID: https://orcid.org/0000-0001-7197-1822)
Institutions
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1002/alr.70019
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Burroughs Wellcome Fund
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Center for Advancing Translational Sciences