Flash Communication: An <i>ortho</i>-Trifluoromethylphenyl Substituted Phosphine Ligand for Applications in Gold(I) Catalysis
Synthesis of the new bulky phosphine ligand di-(1‑adamantyl)-2-trifluoromethyphenylphosphine is reported, which coordinates with the trifluoromethyl group projected toward the metal center and exhibits a %<i>V</i> <sub>bur</sub> of 47.3%. Well-defined gold-(I) derivatives demonstrate higher catalytic activity for the cycloisomerization of 4-fluoro-<i>N</i>-(prop-2-yn-1-yl)-benzamide than di-(1‑adamantyl)-2-biphenylphosphine (AdJohnPhos) and di-(1‑adamantyl)-phenylphosphine analogues.
Authors
- Adrian B. Chaplin (ORCID: https://orcid.org/0000-0003-4286-8791)
- Nil Roig (ORCID: https://orcid.org/0000-0003-4688-4529)
- Itxaso Bustos (ORCID: https://orcid.org/0000-0001-9404-0051)
Institutions
- Vrije Universiteit Brussel (BE)
- University of the Basque Country (ES)
- University of Warwick (GB)
Publication Details
- Journal
- Organometallics
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1021/acs.organomet.5c00240
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00