Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide
Resistance genes are spread through various MGEs, including plasmids and transposons. Our findings suggest that multiple factors influence MGE prevalence and their transposability, thereby shaping the MGE population and transmission pathways. Some MGEs have a wider host range, which could make them more important for mobilizing genes. We also identified 103 resistance genes potentially mobilised by MGEs, which could increase their transmissibility to unrelated bacteria.
Authors
- Amjad Ali (ORCID: https://orcid.org/0000-0002-0486-4661)
- Kaunda Yamba (ORCID: https://orcid.org/0000-0003-1777-8305)
- Paula Díaz (ORCID: https://orcid.org/0000-0002-8252-5622)
- Zenat Zebin Hossain (ORCID: https://orcid.org/0000-0002-6238-0323)
- Viravarn Luvira (ORCID: https://orcid.org/0000-0001-9270-3720)
- Henrik Westh (ORCID: https://orcid.org/0000-0001-5681-647X)
- LeeAnn Turnbull
- Margaret Ip (ORCID: https://orcid.org/0000-0003-1291-6537)
- Arif Al-Hamad (ORCID: https://orcid.org/0000-0003-0148-3131)
- Markus Hans Kristofer Johansson (ORCID: https://orcid.org/0000-0001-8485-9143)
- Ini Adebiyi (ORCID: https://orcid.org/0000-0002-6181-0918)
- Philip Nwajiobi-Princewill
- Thomas Nordahl Petersen (ORCID: https://orcid.org/0000-0002-2484-5716)
- Anita Blomfeldt (ORCID: https://orcid.org/0000-0003-2044-412X)
- Irmak Baran (ORCID: https://orcid.org/0000-0001-6729-948X)
- Victorien Tamègnon Dougnon (ORCID: https://orcid.org/0000-0001-9047-7299)
- Frank M. Aarestrup (ORCID: https://orcid.org/0000-0002-7116-2723)
- Kafayath Fabiyi (ORCID: https://orcid.org/0009-0007-7734-2454)
- Claire Duployez (ORCID: https://orcid.org/0000-0001-8073-6111)
- Iruka N. Okeke (ORCID: https://orcid.org/0000-0002-1694-7587)
- Wantana Paveenkittiporn
- Solomon Asante-Sefa (ORCID: https://orcid.org/0000-0002-8383-4910)
- Natalie Weiler Gustafson
- Inácio Mandomando (ORCID: https://orcid.org/0000-0002-1078-2187)
- Oluwafemi Popoola (ORCID: https://orcid.org/0000-0001-8535-7882)
- Réné Dembelé (ORCID: https://orcid.org/0000-0002-9282-8555)
- Nimat Ullah (ORCID: https://orcid.org/0000-0002-7138-1272)
- James Mwansa (ORCID: https://orcid.org/0000-0003-0726-8889)
- Clementina Cocuzza (ORCID: https://orcid.org/0000-0001-6166-1134)
- Mie Møller (ORCID: https://orcid.org/0009-0001-3576-1577)
- Milica Dilas
- Asta Dambrauskienė (ORCID: https://orcid.org/0000-0002-4772-9689)
- Panagiota Maikanti
- Kirstine K. Søgaard (ORCID: https://orcid.org/0000-0003-3624-7999)
- Ivana Mareković (ORCID: https://orcid.org/0000-0002-3471-4285)
- Deyan Donchev (ORCID: https://orcid.org/0000-0001-7447-7627)
- Silva Tafaj (ORCID: https://orcid.org/0000-0003-3777-0095)
- Simon Lévesque (ORCID: https://orcid.org/0000-0002-4356-9702)
- Anélsio Cossa (ORCID: https://orcid.org/0000-0002-3616-8935)
- Linda Sikakwa
- Livia Berlinger
- Mathew Diggle (ORCID: https://orcid.org/0000-0001-5773-0686)
- Pavel Dřevı́nek (ORCID: https://orcid.org/0000-0002-8994-5240)
- Dàmaris Berbel (ORCID: https://orcid.org/0000-0002-3689-3360)
- José E. Villacís (ORCID: https://orcid.org/0000-0003-1478-5374)
- Peter Collignon (ORCID: https://orcid.org/0000-0001-8648-9203)
- Achim J. Kaasch (ORCID: https://orcid.org/0000-0002-6659-6738)
- Sidsel Nag (ORCID: https://orcid.org/0000-0002-3271-7597)
- M.Á. Domínguez (ORCID: https://orcid.org/0000-0003-3107-9586)
- Susan Bradbury
- Ágnes Sonnevend (ORCID: https://orcid.org/0000-0002-7065-1736)
- Mohamed Azzedine Bachtarzi
- Jan Tkadlec (ORCID: https://orcid.org/0000-0002-0892-924X)
- Aderemi Kehinde (ORCID: https://orcid.org/0000-0003-2200-2288)
- Maxime Paluch (ORCID: https://orcid.org/0000-0003-1976-4660)
- Ifeoluwa Akintayo (ORCID: https://orcid.org/0000-0002-4234-7649)
- Natama Magloire
- Isidore Juste Ouindgueta
- Wahiba Amhis
- Laura Elmlund Kohl Birkedahl
- Alexandre Macanze
- Nora Elisabeth Nyquist (ORCID: https://orcid.org/0000-0002-5332-5496)
- Kiri Bocker
- Ikhlas Jarrar
- Timmie Mikkel Lagermann
- Carolina de Albuquerque Lima Duarte (ORCID: https://orcid.org/0000-0001-9086-3739)
- Denise A Daley
- Anthony Onipede
- Habibullah Khan
- Jana Amlerová (ORCID: https://orcid.org/0000-0002-6056-3740)
- Carolina Elisabeth Satán Salazar
- James E. Ussher (ORCID: https://orcid.org/0000-0001-9222-7680)
- Boubacar Coulibaly (ORCID: https://orcid.org/0000-0002-4777-6741)
- Anowara Begoum
Institutions
- Université Joseph Ki-Zerbo (BF)
- Lithuanian University of Health Sciences (LT)
- University Hospital Centre Zagreb (HR)
- Karadeniz Technical University (TR)
- Chinese University of Hong Kong (HK)
- University of Ibadan (NG)
- University of Dhaka (BD)
- Mahidol University (TH)
- Khyber Teaching Hospital (PK)
- Lozenetz Hospital (BG)
- Akershus University Hospital (NO)
- Nicosia General Hospital (CY)
- Fiona Stanley Hospital (AU)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Hvidovre Hospital (DK)
- Bellvitge University Hospital (ES)
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics (LT)
- University Hospital of Basel (CH)
- University Teaching Hospital (ZM)
- Canberra Hospital (AU)
- Centre Hospitalier Universitaire de Lille (FR)
- Lusaka Apex Medical University (ZM)
- Pontificia Universidad Católica del Ecuador (EC)
- Bioanalytica (Switzerland) (CH)
- University Hospital in Motol (CZ)
- National Hospital Abuja (NG)
- Instituto Nacional de Investigación en Salud Pública (EC)
- University Hospital Plzen (CZ)
- Qatif Central Hospital (SA)
- Manhiça Health Research Centre (MZ)
- Université d'Abomey-Calavi (BJ)
- Centre National de Semences Forestières (BF)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Spitali Universitar Shefqet Ndroqi (AL)
- National Institute of Health of Thailand (TH)
- Southern Community Laboratories (New Zealand) (NZ)
- Ministerio de Salud Pública y Bienestar Social (PY)
- Queen Ingrid's Hospital (GL)
- Instituto Nacional de Salud (CO)
- Centre Hospitalo-Universitaire Bab El Oued (DZ)
- Centre Hospitalier de Valenciennes (FR)
- Ghana Health Service (GH)
- Centre de Recherche en Santé de Nouna (BF)
- Obafemi Awolowo University (NG)
- Arab American University (PS)
- University of Milano-Bicocca (IT)
- Universitat de Barcelona (ES)
- University of Pecs (HU)
- University of Otago (NZ)
- National University of Sciences and Technology (PK)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Technical University of Denmark (DK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1371/journal.pone.0330304
- Citations
- 5
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.96
Funders
- European Commission
- Novo Nordisk
- Novo Nordisk Fonden