Antimicrobial and immunomodulatory activity of natural bioactive compounds – an in vitro investigation with potential applications in managing Hidradenitis Suppurativa
These findings underscore the potential of natural bioactive compounds and their combinations as promising candidates for further investigation in managing skin infections and inflammation-related disorders, including HS. Future studies are essential to optimize formulations, evaluate compound stability, cytotoxicity and skin penetration and establish efficacy <i>in vivo</i>, paving the way for the development of well-tolerated and effective topical formulations.
Authors
- Eliza Oprea (ORCID: https://orcid.org/0000-0001-7051-4136)
- Corina Ioana Cucu (ORCID: https://orcid.org/0000-0002-3097-846X)
- Veronica Lazăr (ORCID: https://orcid.org/0000-0001-7247-2582)
- Yiannis Kourkoutas (ORCID: https://orcid.org/0000-0003-2842-7666)
- Carmen Curuțiu (ORCID: https://orcid.org/0000-0002-4608-4487)
- Mara Mădălina Mihai (ORCID: https://orcid.org/0000-0002-1436-0088)
- Ariana Hudiță (ORCID: https://orcid.org/0000-0002-9439-9432)
- Adrian Ionascu (ORCID: https://orcid.org/0000-0003-4451-7928)
- Alina Maria Holban (ORCID: https://orcid.org/0000-0002-1257-5042)
- Lia-Mara Diţu (ORCID: https://orcid.org/0000-0002-6593-255X)
- Florica Marinescu
- Valentina-Alexandra Badaluta
Institutions
- University of Bucharest (RO)
- Democritus University of Thrace (GR)
- Carol Davila University of Medicine and Pharmacy (RO)
- Emergency University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1608269
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitatea din București