GPR41 and GPR43 modulate rodent pancreatic α-cell function and growth
These findings position GPR41 as a promising therapeutic target for modulating hyperglucagonemia and improving glycemic control in T2D, supporting its translational relevance in diabetes intervention strategies.
Authors
- Laura Marroquí (ORCID: https://orcid.org/0000-0003-2931-9317)
- Fernando Escrivá (ORCID: https://orcid.org/0000-0002-9936-0721)
- Elisa Fernández‐Millán (ORCID: https://orcid.org/0000-0002-2807-3776)
- Atenea A. Perez-Serna (ORCID: https://orcid.org/0000-0002-7594-6365)
- A Sánchez-Roncero
- José C. Segovia (ORCID: https://orcid.org/0000-0003-4101-6124)
- Tamara Fernández‐Marcelo (ORCID: https://orcid.org/0000-0001-6550-3838)
- Carmen Álvarez (ORCID: https://orcid.org/0000-0003-1874-1045)
- Rebeca Sánchez‐Domínguez (ORCID: https://orcid.org/0000-0002-2073-2810)
- Beatriz G. Gálvez (ORCID: https://orcid.org/0000-0002-8082-9323)
- María Ángeles Martín (ORCID: https://orcid.org/0000-0001-8173-4521)
- Omaira Alberquilla-Fernandez
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Universidad Complutense de Madrid (ES)
- Institut Pasteur (FR)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.lfs.2025.123913
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00