Concentrations of sex steroids in fluid from human antral follicles are dynamic and characterize transition from follicular recruitment to dominance
This is the first study to comprehensively map intrafollicular concentrations of all major sex steroids in FF, alongside gene expression of key enzymes in granulosa cells, across the follicular phase of the menstrual cycle using liquid chromatography-tandem mass spectrometry. These findings enhance our understanding of hormonal regulation and the timing mechanisms that govern human follicle development and ovarian function.
Authors
- Anders Hay‐Schmidt (ORCID: https://orcid.org/0000-0001-9984-7014)
- Bjarne Styrishave (ORCID: https://orcid.org/0000-0003-1619-2468)
- Linn Salto Mamsen (ORCID: https://orcid.org/0000-0002-8827-7519)
- Claus Yding Andersen (ORCID: https://orcid.org/0000-0001-7681-253X)
- Mengxue Zheng (ORCID: https://orcid.org/0000-0002-2447-6658)
- Malene Louise Johannsen (ORCID: https://orcid.org/0009-0003-4552-3147)
Institutions
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
Publication Details
- Journal
- Fertility and Sterility
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.fertnstert.2025.08.004
- Citations
- 2
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 2.40