Gene expression profile predicts response to antitumor necrosis factor in children with Crohn's disease: A Porto group biobank study, and a systematic review
Increased expression of five genes is associated with higher rate of anti-TNF response in pediatric CD. Prospective studies are now warranted to validate these genes as biomarkers for treatment selection.
Authors
- Véronique Groleau
- A. Azulay (ORCID: https://orcid.org/0000-0003-4952-3729)
- Tobias Schwerd (ORCID: https://orcid.org/0000-0002-2281-4852)
- Danny Ben‐Zvi (ORCID: https://orcid.org/0000-0002-8697-9744)
- Tim Faro (ORCID: https://orcid.org/0000-0001-8805-051X)
- Botros Moalem
- Laurence Chapuy (ORCID: https://orcid.org/0000-0002-2772-3570)
- Séamus Hussey (ORCID: https://orcid.org/0000-0002-9362-0465)
- Jiří Bronský (ORCID: https://orcid.org/0000-0002-2641-7280)
- Lorenzo Norsa (ORCID: https://orcid.org/0000-0003-3322-2921)
- Ohad Atia (ORCID: https://orcid.org/0000-0001-7800-1984)
- Sam Amar (ORCID: https://orcid.org/0000-0002-0051-3434)
- Kelly Grzywacz
- Patrick Walsh (ORCID: https://orcid.org/0000-0002-0130-8766)
- Oren Ledder (ORCID: https://orcid.org/0000-0001-8109-814X)
- Michal Kubát (ORCID: https://orcid.org/0000-0002-2500-0176)
- Kolja Siebert
- Raffi Lev‐Tzion (ORCID: https://orcid.org/0000-0001-5193-9577)
- Michael Bergel
- Dan Turner (ORCID: https://orcid.org/0000-0002-3704-3325)
- Gili Focht
- M Aloi
- Ronen Michailevitch
Institutions
- Hebrew University of Jerusalem (IL)
- Trinity College Dublin (IE)
- Jerusalem Institute for Israel Studies (IL)
- Shaare Zedek Medical Center (IL)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Children's Health Ireland at Crumlin (IE)
- University Hospital in Motol (CZ)
- Ospedale Papa Giovanni XXIII (IT)
- University Children's Hospital Tübingen (DE)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Our Lady's Hospital (IE)
- Ludwig-Maximilians-Universität München (DE)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1002/jpn3.70197
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00