Gene expression profile predicts response to antitumor necrosis factor in children with Crohn's disease: A Porto group biobank study, and a systematic review

Increased expression of five genes is associated with higher rate of anti-TNF response in pediatric CD. Prospective studies are now warranted to validate these genes as biomarkers for treatment selection.

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Publication Details

Journal
Journal of Pediatric Gastroenterology and Nutrition
Published
2025-08-17
DOI
https://doi.org/10.1002/jpn3.70197
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
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article

Gene expression profile predicts response to antitumor necrosis factor in children with Crohn's disease: A Porto group biobank study, and a systematic review

Véronique Groleau, A. Azulay, Tobias Schwerd, Danny Ben‐Zvi et al.
Journal of Pediatric Gastroenterology and Nutrition
Inflammatory Bowel Disease
article

Gene expression profile predicts response to antitumor necrosis factor in children with Crohn's disease: A Porto group biobank study, and a systematic review

Véronique Groleau, A. Azulay, Tobias Schwerd, Danny Ben‐Zvi, Tim Faro, Botros Moalem, Laurence Chapuy, Séamus Hussey, Jiří Bronský, Lorenzo Norsa, Ohad Atia, Sam Amar, Kelly Grzywacz, Patrick Walsh, Oren Ledder, Michal Kubát, Kolja Siebert, Raffi Lev‐Tzion, Michael Bergel, Dan Turner, Gili Focht, M Aloi, Ronen Michailevitch
article en

Abstract

Increased expression of five genes is associated with higher rate of anti-TNF response in pediatric CD. Prospective studies are now warranted to validate these genes as biomarkers for treatment selection.

Journal of Pediatric Gastroenterology and NutritionVol. 81(5)
Hebrew University of Jerusalem (IL), Trinity College Dublin (IE), Jerusalem Institute for Israel Studies (IL), Shaare Zedek Medical Center (IL), Centre Hospitalier Universitaire Sainte-Justine (CA), Children's Health Ireland at Crumlin (IE), University Hospital in Motol (CZ), Ospedale Papa Giovanni XXIII (IT), University Children's Hospital Tübingen (DE), Ospedale dei Bambini Vittore Buzzi (IT), Our Lady's Hospital (IE), Ludwig-Maximilians-Universität München (DE), Sapienza University of Rome (IT)
Openalex Percentile: Top 77%
Inflammatory Bowel Disease
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