Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice
This study confirms the ability of invasive isolates of N. meningitidis to cause more severe infections than carriage isolates in transgenic mice. The porB expressed in invasive isolates seems to contribute to their higher virulence compared to carriage isolates, although this effect may depend on the genomic context. Notably, differences in virulence were mainly observed among serogroup C and W isolates.
Authors
- Ala‐Eddine Deghmane (ORCID: https://orcid.org/0000-0003-2887-1732)
- Muhamed‐Kheir Taha (ORCID: https://orcid.org/0000-0002-0716-3174)
- Lorraine Eriksson (ORCID: https://orcid.org/0009-0004-4040-4891)
- Olof Säll (ORCID: https://orcid.org/0000-0003-1999-3383)
- Sara Thulin Hedberg
- Paula Mölling (ORCID: https://orcid.org/0009-0000-1143-9105)
- Cecilia Klanger
Institutions
- Institut Pasteur (FR)
- Örebro University (SE)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1186/s12866-025-04246-3
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Örebro Universitet