Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models
In the PNI and NPNI groups, 35 gut microbiota species exhibited significant variations in abundance. The differential intestinal microbiota associated with PNI in colorectal cancer may modulate the neuroinvasion process via a variety of potential biological mechanisms. The RF and MLP predictive models show considerable accuracy in predicting CRC-PNI status and are of reference value.
Authors
- Tianyi Ye (ORCID: https://orcid.org/0000-0002-8242-5242)
- Mingjian Qin
- Xinting Yang (ORCID: https://orcid.org/0000-0002-9042-1815)
- Yongqi Huang (ORCID: https://orcid.org/0009-0005-5962-9449)
- Jianping Zhao (ORCID: https://orcid.org/0000-0003-3057-5617)
- Guoxi Li (ORCID: https://orcid.org/0000-0001-8442-8861)
- Xiaoliang Huang (ORCID: https://orcid.org/0009-0006-6800-0770)
- Fuhai He (ORCID: https://orcid.org/0000-0002-1780-9389)
- Jungang Liu
- Chuanbin Chen (ORCID: https://orcid.org/0000-0003-2616-0654)
- Jing‐Long Huang (ORCID: https://orcid.org/0000-0002-3530-7753)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-1215-1661)
- Zigui Huang
- Binzhe Tang
- Weizhong Tang (ORCID: https://orcid.org/0000-0001-6203-1556)
- Qingmin Chen (ORCID: https://orcid.org/0000-0002-5645-3338)
- S Liu (ORCID: https://orcid.org/0000-0002-2131-6640)
- C. S. Long
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1186/s12866-025-04179-x
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangxi Province
- Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi
- Youth Science Foundation of Guangxi Medical University