Ma Xing Shi Gan Decoction alleviates lipopolysaccharide-induced pneumonia by inhibiting NLRP3 inflammasome activation via AMPK/mTOR/ULK1-mediated autophagy
MXSG activates the AMPK/mTOR/ULK1 pathway, promoting autophagy and inhibiting excessive NLRP3 inflammasome activation induced by LPS. This subsequently reduces inflammatory cytokine (IL-1β, IL-18) levels, thereby mitigating LPS-triggered lung inflammation. The primary active compounds of MXSG that promote autophagy are amygdalin, licoricesaponin G2, and daidzein. These findings offer fresh perspectives on how MXSG mitigates pneumonia, highlighting the anti-inflammatory effects, and reveal potential therapeutic targets for future use in integrative medicine.
Authors
- Fangfang Sun (ORCID: https://orcid.org/0000-0002-5507-749X)
- Yong-Kuan Ji
- Lin Jiang (ORCID: https://orcid.org/0000-0002-7114-0794)
- Xiaohong Gu (ORCID: https://orcid.org/0000-0001-8361-9455)
- Lina Liu (ORCID: https://orcid.org/0000-0002-5511-2945)
- Su Chen (ORCID: https://orcid.org/0000-0001-7688-9051)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Qianqian Li (ORCID: https://orcid.org/0000-0002-5340-5218)
- Hui Liu (ORCID: https://orcid.org/0000-0003-3773-174X)
- Chen Bai (ORCID: https://orcid.org/0000-0001-7155-2628)
- Tiegang Liu (ORCID: https://orcid.org/0000-0001-5226-441X)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.jep.2025.120418
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42