First the B cells fall, then the T cells follow: temporal immunological shift with ocrelizumab in multiple sclerosis
OCR exerts a biphasic immunomodulatory effect, with rapid direct suppression of B cell pathways followed by delayed indirect modulation of T cell-mediated immunity.
Authors
- Gianmarco Abbadessa (ORCID: https://orcid.org/0000-0001-8912-3055)
- Luigi Lavorgna (ORCID: https://orcid.org/0000-0003-4625-4236)
- Simona Bonavita (ORCID: https://orcid.org/0000-0002-8561-9720)
- Elisabetta Maida (ORCID: https://orcid.org/0009-0003-6505-0834)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1007/s00415-025-13297-5
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi della Campania Luigi Vanvitelli