Polypharmacological effects of honokiol on allergic rhinitis: Modulation of TMEM16A, TRPV1, and calcium signaling
Our findings revealed that the therapeutic effect of honokiol stems from its novel polypharmacological action on multiple ion channels and critical immune cells. By suppressing both early- (mast cell-driven) and late-phase (T cell-driven) allergic responses, this multitarget approach represents a new strategy for AR treatment that could overcome the limitations of current single-target therapies.
Authors
- Nhung Thi Hong Van (ORCID: https://orcid.org/0000-0001-7738-8777)
- Joo‐Hyun Nam (ORCID: https://orcid.org/0000-0001-8300-6974)
- Nguyen D. Vo (ORCID: https://orcid.org/0000-0003-2530-971X)
- Hong Thi Lam Phan (ORCID: https://orcid.org/0000-0001-9203-6489)
- Jin Tae Kim (ORCID: https://orcid.org/0000-0002-1739-9885)
- Hyun Jong Kim (ORCID: https://orcid.org/0000-0002-6130-7028)
- Joohan Woo (ORCID: https://orcid.org/0000-0001-5152-8057)
- Woo Kyung Kim (ORCID: https://orcid.org/0000-0003-0359-3967)
- Yu-Ran Nam
Institutions
- Dongguk University (KR)
- Anyang University (KR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.biopha.2025.118460
- Citations
- 2
- Primary Topic
- Magnolia and Illicium research
- Type
- article
- Field-Weighted Citation Impact
- 2.05