An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits
Blood DNA methylation near ZFP57 was associated (fwer < 0.1) with SRS in the full population sample and appears to be largely driven by trait heterogeneity within the autism case group. Our results indicate DNA methylation associations with ASD quantitative traits are observable in a population and provide insights into specific biologic changes related to autism trait heterogeneity.
Authors
- M. Daniele Fallin (ORCID: https://orcid.org/0000-0002-9948-3908)
- Homayoon Farzadegan
- Valerie N. Morrill (ORCID: https://orcid.org/0000-0003-3245-304X)
- Aimee Alexander (ORCID: https://orcid.org/0000-0002-3983-8615)
- Christine Ladd‐Acosta (ORCID: https://orcid.org/0000-0002-7697-3998)
- Genevieve L. Wojcik (ORCID: https://orcid.org/0000-0001-7206-8088)
- Ellen M. Howerton (ORCID: https://orcid.org/0000-0002-2238-1954)
- Gabriel S. Dichter (ORCID: https://orcid.org/0000-0003-3407-5417)
- Lisa Croen (ORCID: https://orcid.org/0000-0001-7849-9428)
- Lisa D. Wiggins (ORCID: https://orcid.org/0000-0001-9283-7294)
- Jason Daniels
- Kelly S. Benke (ORCID: https://orcid.org/0000-0002-5628-495X)
- Ashley Song (ORCID: https://orcid.org/0000-0002-1663-5751)
- Rose Schrott (ORCID: https://orcid.org/0000-0001-8224-9245)
- Amanda L. Tapia (ORCID: https://orcid.org/0000-0001-7348-7372)
- Heather E. Volk (ORCID: https://orcid.org/0000-0002-5415-2494)
Institutions
- University of North Carolina at Chapel Hill (US)
- Centers for Disease Control and Prevention (US)
- Kaiser Permanente (US)
- Johns Hopkins University (US)
- Emory University (US)
- National Center on Birth Defects and Developmental Disabilities (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1186/s11689-025-09637-1
- Citations
- 3
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- Autism Speaks
- Burroughs Wellcome Fund
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute of Environmental Health Sciences