Long‐term impact of white matter hyperintensities and amyloid beta on thalamic subregions in cerebral small vessel disease: A prospective cohort study
Patients with cerebral small vessel disease (CSVD) exhibit selective atrophy in thalamic subregions compared to healthy controls (HCs). Thalamic white matter hyperintensity (WMH) burden strongly predicts mediodorsal-parafascicular and lateral geniculate nucleus atrophy in patients with CSVD. Plasma amyloid beta dynamics differentially influence thalamic integrity in CSVD compared to HCs.
Authors
- Lingfei Guo (ORCID: https://orcid.org/0000-0002-4885-625X)
- Yiwen Chen (ORCID: https://orcid.org/0009-0007-9411-0145)
- Zhenyu Cheng (ORCID: https://orcid.org/0009-0000-0717-3228)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-0641-8411)
- Changhu Liang (ORCID: https://orcid.org/0000-0003-3796-2978)
- Yena Che (ORCID: https://orcid.org/0000-0003-4742-4778)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0002-8133-6715)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-9675-5322)
- Jing Li (ORCID: https://orcid.org/0000-0001-9392-6600)
- Meng Li (ORCID: https://orcid.org/0000-0002-8320-5241)
- Pengcheng Liang (ORCID: https://orcid.org/0009-0007-7392-2566)
- Na Wang (ORCID: https://orcid.org/0000-0001-6191-4760)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Shandong Provincial Hospital (CN)
- Jena University Hospital (DE)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70553
- Citations
- 3
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Medical and Health Science and Technology Development Project of Shandong Province