Potent antimicrobial and anti-biofilm effects of Uvaria chamae on Staphylococcus aureus strains via potential cell wall interference and lack of resistance induction
U. chamae root extract exhibits strong, selective antibacterial activity with low toxicity, no resistance induction, and in vivo efficacy. These findings support its potential as a locally relevant option to combat AMR in Africa.
Authors
- Karmen Kapp (ORCID: https://orcid.org/0000-0002-3239-7108)
- Matej Zore (ORCID: https://orcid.org/0000-0003-4230-1111)
- Victorien Tamègnon Dougnon (ORCID: https://orcid.org/0000-0001-9047-7299)
- Boris Brice Legba (ORCID: https://orcid.org/0000-0003-2622-4363)
- Leena Hanski (ORCID: https://orcid.org/0000-0002-3121-8542)
- Maarit Ylätalo (ORCID: https://orcid.org/0000-0002-1552-5956)
- Inés Reigada (ORCID: https://orcid.org/0000-0003-4799-2011)
- Nina H. Sipari (ORCID: https://orcid.org/0000-0002-0786-2493)
- Eskyl Togbé
- Toussaint Sovègnon (ORCID: https://orcid.org/0000-0001-5349-5025)
Institutions
- University of Helsinki (FI)
- Helsinki Institute of Physics (FI)
- Université d'Abomey-Calavi (BJ)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.jep.2025.120434
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00