Co-prescribing of antidepressants and opioids for non-cancer pain in England, 2010–2019: a descriptive study using CPRD primary care electronic health records
There is a substantial group of people co-prescribed opioids and antidepressants in England, including combinations that may be less effective. This information will be useful to help GPs, dispensing professionals, policymakers and others understand how many people in the UK may be at risk of harm from using both types of medicines at the same time, and which groups are particularly affected. Future research should determine whether there are higher risks of adverse events in these co-prescribed groups.
Authors
- Roger Knaggs (ORCID: https://orcid.org/0000-0003-1646-8321)
- Anthony Avery (ORCID: https://orcid.org/0000-0001-7591-4438)
- Ruth H. Jack (ORCID: https://orcid.org/0000-0003-4009-020X)
- Rebecca M. Joseph (ORCID: https://orcid.org/0000-0002-0147-0712)
- John Butler (ORCID: https://orcid.org/0000-0001-7407-0990)
- Richard Morriss (ORCID: https://orcid.org/0000-0003-2910-4121)
- Dave Waldram
- Carol Coupland (ORCID: https://orcid.org/0000-0002-2327-3306)
- L. Gerrard
- Debbie Butler
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Institute of Mental Health (GB)
- NIHR MindTech MedTech Co-operative (GB)
- Nottingham Biomedical Research Centre (GB)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- BMC Primary Care
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1186/s12875-025-02956-1
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care