Rationale, design, and baseline characteristics of the multicENter, randomized, open-label, parallel group, study to evaluate the use of sacubitril/valsartan in HeartMate 3 left ventricular assist device recipients (ENVAD-HF)
ENVAD-HF is the first prospective randomized controlled trial of pharmacologic therapy for the management of BP in stable recipients with HM3 LVADs achieving target enrollment. It will provide data on safety, tolerability, and insights on efficacy of sacubitril/valsartan versus SOC used for treating BP.
Authors
- Filip Lončarić (ORCID: https://orcid.org/0000-0002-7865-1108)
- Nir Y. Uriel (ORCID: https://orcid.org/0000-0003-2301-3587)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Frank Thomas Ruschitzka (ORCID: https://orcid.org/0000-0001-5972-0596)
- Ulrich P. Jorde (ORCID: https://orcid.org/0000-0002-9476-6466)
- Jasper J. Brugts (ORCID: https://orcid.org/0000-0002-5522-9318)
- Ivo Planinc (ORCID: https://orcid.org/0000-0003-0561-6704)
- Markéta Hegarová
- Linda W. van Laake (ORCID: https://orcid.org/0000-0002-5027-0661)
- Mandeep R. Mehra (ORCID: https://orcid.org/0000-0001-8683-7044)
- Filip Puškarić (ORCID: https://orcid.org/0000-0001-5519-439X)
- Maja Čikeš (ORCID: https://orcid.org/0000-0002-4772-5549)
- Nina Jakuš (ORCID: https://orcid.org/0000-0001-7304-1127)
- Igor Rudež (ORCID: https://orcid.org/0000-0002-7735-6721)
- Davor Miličić (ORCID: https://orcid.org/0000-0001-9101-1570)
- Paweł Rubiś (ORCID: https://orcid.org/0000-0002-6979-3411)
- Scott D. Solomon
Institutions
- Jagiellonian University (PL)
- Brigham and Women's Hospital (US)
- University Hospital Centre Zagreb (HR)
- University of Zagreb (HR)
- Columbia University Irving Medical Center (US)
- University Hospital Dubrava (HR)
- University Medical Center Utrecht (NL)
- University Hospital of Zurich (CH)
- John Paul II Hospital (PL)
- Montefiore Health System (US)
- Institute of Clinical and Experimental Medicine (CZ)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Cardiac Failure
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.cardfail.2025.07.015
- Citations
- 2
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 1.35