m5C modification of LINC01082 inhibits osteosarcoma progression by modulating the miR-543-TNRC6A axis
Our study highlights a novel m5C-dependent regulatory mechanism of LINC01082, and demonstrates the potential of CRISPR/dCas13b-NSUN2-mediated m5C editing to functionally modulate this lncRNA and suppress osteosarcoma progression.
Authors
- Yawei Hu (ORCID: https://orcid.org/0000-0002-5993-6765)
- Jiawen Wu (ORCID: https://orcid.org/0000-0002-6286-5937)
- Jianhua Zhou
- Zengfeng Guo
- Wang Zhang (ORCID: https://orcid.org/0000-0002-9830-8104)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-9513-9288)
- Liyang Zhang (ORCID: https://orcid.org/0000-0002-4054-1667)
- Ming Gong (ORCID: https://orcid.org/0000-0001-5137-836X)
- Huaping Zeng
Institutions
- Longgang Central Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.tranon.2025.102502
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94