Genetic evolution of myeloproliferative neoplasms from chronic phase to blastic phase: An analysis of 46 paired samples
MPN transformation involves complex clonal evolution, with frequent clonal hematopoiesis-related mutations preceding driver mutations, preserved CALR, acquisition of TP53, RUNX1 and signaling mutations, and JAK2-V617F loss linked to poorer survival during BP transformation, which may influence therapeutic decisions.
Authors
- Ming‐Chung Kuo (ORCID: https://orcid.org/0000-0003-1324-5034)
- Ying‐Jung Huang
- Hsiao‐Wen Kao (ORCID: https://orcid.org/0000-0002-3586-5317)
- Lee‐Yung Shih (ORCID: https://orcid.org/0000-0003-1866-7922)
- Ting‐Yu Huang (ORCID: https://orcid.org/0000-0002-2244-6535)
- Hung Chang (ORCID: https://orcid.org/0000-0001-8451-0304)
- Jin‐Hou Wu
- Tung‐Liang Lin (ORCID: https://orcid.org/0000-0002-9532-749X)
Institutions
- Chang Gung University (TW)
- Taipei Municipal YangMing Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cancer
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1002/cncr.70048
- Citations
- 1
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63