Ubiquitin Ligase <scp>MDM2</scp> Regulates Chondrocyte Damage, Ferroptosis, and Oxidative Stress by Modulating the Ubiquitination Level of <scp>CDKN1A</scp>
MDM2 downregulated the level of CDKN1A in chondrocytes by mediating the ubiquitination modification of CDKN1A, leading to impaired chondrocyte viability and inducing ferroptosis and oxidative stress.
Authors
- Jun Fan (ORCID: https://orcid.org/0000-0001-6637-9891)
- Lin Huang (ORCID: https://orcid.org/0000-0003-3264-1374)
- Junlei Song
- Ao Li (ORCID: https://orcid.org/0000-0002-6364-1898)
- Xiaosong Li (ORCID: https://orcid.org/0000-0001-5533-7995)
- Kaihong Gui
Institutions
- Huanggang Central Hospital (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/1756-185x.70384
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00