Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases

This study highlights a significant risk of infection associated with clindamycin prophylaxis in penicillin-allergic patients undergoing orthognathic surgery. Cefazolin proved effective in preventing SSIs. These findings underscore the urgent need for updated, evidence-based prophylactic protocols in maxillofacial surgery, particularly for patients with beta-lactam allergies.