β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways

NMN supplementation provides protection against alcoholic liver injury in a mouse model, potentially through the upregulation of the cellular NAD<sup>+</sup>/ SIRT1 pathway. This upregulation enhances antioxidant and anti-inflammatory activities and improves intestinal permeability.

Authors

Xinxin Yang (ORCID: https://orcid.org/0000-0002-2024-4307)
Haoyue Sun (ORCID: https://orcid.org/0009-0003-3358-7100)
Ji Zhang (ORCID: https://orcid.org/0000-0001-7005-6980)
Yingcong Yu (ORCID: https://orcid.org/0000-0001-8705-9678)
Yuxian Lin
Endian Zheng

Institutions

Shanghai University (CN)
Shanghai University of Engineering Science (CN)
Wenzhou Medical University (CN)

Publication Details

Journal: Hereditas
Published: 2025-08-16
DOI: https://doi.org/10.1186/s41065-025-00529-x
Citations: 2
Primary Topic: Alcohol Consumption and Health Effects
Type: article
Field-Weighted Citation Impact: 2.94

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article

β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways

Xinxin Yang, Haoyue Sun, Ji Zhang, Yingcong Yu et al.

Aug 16, 2025

2 citations

Hereditas

Alcohol Consumption and Health Effects

2.94

article

β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways

Xinxin Yang, Haoyue Sun, Ji Zhang, Yingcong Yu, Yuxian Lin, Endian Zheng

August 16, 2025article en

2 citations

Abstract

NMN supplementation provides protection against alcoholic liver injury in a mouse model, potentially through the upregulation of the cellular NAD<sup>+</sup>/ SIRT1 pathway. This upregulation enhances antioxidant and anti-inflammatory activities and improves intestinal permeability.

HereditasVol. 162(1)

Shanghai University (CN), Shanghai University of Engineering Science (CN), Wenzhou Medical University (CN)

Openalex Percentile: Top 9%

Alcohol Consumption and Health Effects

2.94

DOI Open Access PDF OpenAlex

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β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways — Xinxin Yang, Haoyue Sun, et al. · Hereditas (2025) | TGRS Research Map | TGRS