Intestinal <i>Fut2</i> deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism
Loss of intestinal epithelial fucosylation exacerbates alcohol-related liver injuries. Intestinal epithelial deletion of Fut2 disrupts nicotinamide (NAM) metabolism due to the decline in bacterial nicotinamidase (PncA). Supplemented with pncA overexpressed E.coli to restore gut PncA levels can improve liver damage in alcohol-induced intestinal epithelial Fut2 deletion mice.
Authors
- Liuying Chen
- Shenglan Yang (ORCID: https://orcid.org/0000-0002-4807-950X)
- Huikuan Chu (ORCID: https://orcid.org/0000-0001-5349-8429)
- Xiaohua Hou (ORCID: https://orcid.org/0000-0002-3694-2126)
- Wenkang Gao (ORCID: https://orcid.org/0000-0003-0187-5573)
- Zhongwei Yin (ORCID: https://orcid.org/0009-0005-4102-3051)
- Hang Yuan
- Luorui Shang
- Shuyan Wang (ORCID: https://orcid.org/0009-0003-3764-3843)
- Shuhan Wang (ORCID: https://orcid.org/0000-0002-6562-3351)
Institutions
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/ctm2.70447
- Citations
- 2
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Wuhan Union Hospital
- National Key Research and Development Program of China