Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA
Our study identified a previously unknown mechanism of how TGFβ1 drives cellular senescence and liver fibrosis through NAT10-mediated ac4C mRNA modification.
Authors
- Panlong Li
- Weicheng Liang (ORCID: https://orcid.org/0000-0001-5425-5402)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-5055-3637)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-2675-9213)
- Xuyun Peng
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University Cancer Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s13073-025-01520-x
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province