Spleen Tyrosine Kinase Inhibition Mitigates Hemin-Induced Thromboinflammation in an Organ-Specific Manner in Sickle Cell Mice
These findings underscore the critical role of Syk in vascular thrombo-inflammation and hypoperfusion in SCD, suggesting that Syk inhibition is a promising strategy to reduce VOC, improve renal and pulmonary perfusion, and reduce organ damage.
Authors
- Simon J. Cleary (ORCID: https://orcid.org/0000-0001-5573-6363)
- Gina Perrella (ORCID: https://orcid.org/0000-0002-0516-4261)
- Phillip L.R. Nicolson (ORCID: https://orcid.org/0000-0002-4843-2975)
- Neena Kalia (ORCID: https://orcid.org/0000-0003-2960-7829)
- Eman Hassan (ORCID: https://orcid.org/0000-0002-0696-6848)
- Alexander Brill (ORCID: https://orcid.org/0000-0002-4558-0390)
- Steve P. Watson (ORCID: https://orcid.org/0000-0002-7846-7423)
- Juma El-Awaisi (ORCID: https://orcid.org/0000-0002-2336-7417)
- Beata Grygielska (ORCID: https://orcid.org/0000-0002-0018-9507)
- Jordan D. Dimitrov (ORCID: https://orcid.org/0000-0001-8536-8995)
- Julie Rayes (ORCID: https://orcid.org/0000-0003-0499-6880)
- Dean Kavanagh (ORCID: https://orcid.org/0000-0001-9459-1494)
- Nicolas Mayor (ORCID: https://orcid.org/0009-0003-6934-2500)
- V. V. Tinkova (ORCID: https://orcid.org/0009-0008-4796-6132)
Institutions
- Délégation Paris 5 (FR)
- Inserm (FR)
- Délégation Paris 7 (FR)
- King's College London (GB)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- West Midlands Deanery (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1161/atvbaha.124.322072
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00