HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
HACD3 promotes the malignant progression of NSCLC by interacting with MKK7 and MAPK10 to suppress MAPK signaling, independent of its canonical dehydratase activity. The identification of a critical pro-oncogenic domain (aa231-259) suggests that targeting HACD3, potentially via this region, represents a novel therapeutic strategy for NSCLC.
Authors
- Qindan Du
- Xiaoying Wang (ORCID: https://orcid.org/0000-0003-1771-1960)
- Ying Li (ORCID: https://orcid.org/0000-0001-7370-1754)
- Yong Zhao
- Huijun Liang (ORCID: https://orcid.org/0000-0001-7344-1489)
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1186/s12885-025-14621-y
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangnan University